Mikael Rydén gained his M.D. at the Karolinska Institute in 1996. He defended his PhD in molecular neurobiology at the department of medical biochemistry and biophysics the following year. He changed his research focus to intracellular signaling pathways in human fat cells and their relevance for the development of insulin resistance and type 2 diabetes. Following a two-year post-doctoral stay at the department of medicine he became associate professor in experimental endocrinology in 2002. He was awarded the Young Investigator’s Award in Basic Science from the European Association on the Study of Obesity in 2003 and held between 2003 and 2009 a half-time position for clinical researchers financed by the Swedish Research Council. He became specialist in internal medicine in 2005, endocrinology/diabetology in 2006 and obtained a combined appointment as senior consultant/senior lecturer in 2010. He was appointed professor in clinical and experimental adipose tissue research in 2013 and combines this with clinical work at the Endocrinology Clinic, at Karolinska University Hospital. He is head of the Endocrinology unit at the department of medicine (H7) as well as of the Center for Clinical Metabolic Research in Diabetes within the Diabetes Program at Karolinska Institutet.